tag:blogs.poz.com,2009-03-02:/joseph//36 2011-12-10T22:47:50Z Physician and AIDS Researcher Movable Type 4.34-en tag:blogs.poz.com,2011:/joseph//36.33089 2011-12-10T16:40:02Z 2011-12-10T22:47:50Z

We have known for quite a long time that it's possible to be infected with HIV more than once.

Joseph Sonnabend We have known for quite a long time that it's possible to be infected with HIV more than once. tag:blogs.poz.com,2011:/joseph//36.33019 2011-10-18T16:38:55Z 2011-10-18T20:43:57Z

These trials of the effects of anti-herpes treatment on HIV also represent missed research opportunities.

Joseph Sonnabend These trials of the effects of anti-herpes treatment on HIV also represent missed research opportunities. tag:blogs.poz.com,2011:/joseph//36.32911 2011-08-03T15:41:00Z 2011-08-03T16:35:52Z

Too often the results of prevention trials are presented in ways that exaggerate the benefits of an intervention, and information is withheld that would allow us to more realistically understand the degree to which risk is reduced.

Joseph Sonnabend Too often the results of prevention trials are presented in ways that exaggerate the benefits of an intervention, and information is withheld that would allow us to more realistically understand the degree to which risk is reduced. tag:blogs.poz.com,2011:/joseph//36.32826 2011-06-07T12:53:30Z 2011-06-08T21:11:25Z

Patient autonomy is just a particular instance of individual autonomy, a term that may sound pretty dry and academic but if we used the term individual freedom we would essentially be talking about the same thing.

Joseph Sonnabend Patient autonomy is just a particular instance of individual autonomy, a term that may sound pretty dry and academic but if we used the term individual freedom we would essentially be talking about the same thing. tag:blogs.poz.com,2011:/joseph//36.32791 2011-05-07T12:27:39Z 2011-06-08T21:09:36Z

Interferon is produced in response to viral infections as a first line of defence. But in addition to its antiviral properties interferon also has widespread effects on the immune system and elsewhere, some of which can be harmful if prolonged.

Joseph Sonnabend Interferon is produced in response to viral infections as a first line of defence. But in addition to its antiviral properties interferon also has widespread effects on the immune system and elsewhere, some of which can be harmful if prolonged. tag:blogs.poz.com,2011:/joseph//36.32694 2011-03-05T14:08:38Z 2011-06-08T21:13:38Z

I was prompted to write this entry after reading an important report about HIV and anal cancer which has just appeared in an advance access edition of the Journal, Clinical Infectious Diseases.

Joseph Sonnabend I was prompted to write this entry after reading an important report about HIV and anal cancer which has just appeared in an advance access edition of the Journal, Clinical Infectious Diseases. tag:blogs.poz.com,2011:/joseph//36.3251 2011-01-29T17:07:53Z 2011-06-08T21:15:11Z

Today, I'm going back 24 years to recall - with the help of a few contemporary documents, a significant event in the history of the HIV/AIDS epidemic. This was the introduction of AZT, the first drug to be approved for the treatment of HIV infection.

Joseph Sonnabend Today, I'm going back 24 years to recall - with the help of a few contemporary documents, a significant event in the history of the HIV/AIDS epidemic. This was the introduction of AZT, the first drug to be approved for the treatment of HIV infection. tag:blogs.poz.com,2010:/joseph//36.3154 2010-11-25T13:09:06Z 2011-06-08T21:16:11Z

I may as well jump in immediately: The iPrEx trial of pre-exposure prophylaxis is a failure. Maybe a shocking statement in view of the universally jubilant press reports.

Joseph Sonnabend I may as well jump in immediately: The iPrEx trial of pre-exposure prophylaxis is a failure. Maybe a shocking statement in view of the universally jubilant press reports. tag:blogs.poz.com,2010:/joseph//36.3149 2010-11-24T15:40:50Z 2011-06-08T21:17:12Z

Rather than attempt to deprive Gary Null of his right to free expression the signatories of the letter might consider some of the reasons why his messages might receive a sympathetic hearing among some, with a view to countering those we can.

Joseph Sonnabend Rather than attempt to deprive Gary Null of his right to free expression the signatories of the letter might consider some of the reasons why his messages might receive a sympathetic hearing among some, with a view to countering those we can. tag:blogs.poz.com,2010:/joseph//36.3100 2010-10-19T14:21:04Z 2011-06-08T21:18:55Z

By 1981 we had come to understand that infection and disease are not synonymous terms. But it almost seemed that this important lesson learned at least a century ago had somehow been ignored by some of those producing a detailed picture of the course of HIV infection at a time when so little was known about it.

Joseph Sonnabend By 1981 we had come to understand that infection and disease are not synonymous terms. But it almost seemed that this important lesson learned at least a century ago had somehow been ignored by some of those producing a detailed picture of the course of HIV infection at a time when so little was known about it. tag:blogs.poz.com,2010:/joseph//36.3046 2010-09-20T13:52:39Z 2010-09-20T16:32:59Z

The HIV-1 and HIV-2 epidemics originated from cross species jumps from two different non-human primates. Attempts have been made, in the case of HIV-1, to pinpoint in time when the fateful transfer occurred, as if it were a unique event, rather than something that has probably happened countless times.

Joseph Sonnabend The HIV-1 and HIV-2 epidemics originated from cross species jumps from two different non-human primates. Attempts have been made, in the case of HIV-1, to pinpoint in time when the fateful transfer occurred, as if it were a unique event, rather than something that has probably happened countless times. tag:blogs.poz.com,2010:/joseph//36.2995 2010-08-05T18:51:56Z 2010-08-05T19:42:43Z

Always on the lookout for information on cytomegalovirus (CMV) an article entitled "Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type I Cytokine Signature" caught my eye this morning prompting yet another post, this time a short one on the role of CMV in HIV disease.

Joseph Sonnabend Always on the lookout for information on cytomegalovirus (CMV) an article entitled "Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type I Cytokine Signature" caught my eye this morning prompting yet another post, this time a short one on the role of CMV in HIV disease. tag:blogs.poz.com,2010:/joseph//36.2947 2010-07-13T17:28:50Z 2010-07-13T20:54:16Z

The opinions of the guidelines panel and others who favour starting treatment at higher numbers are most certainly not held by all experts in HIV medicine...

Joseph Sonnabend The opinions of the guidelines panel and others who favour starting treatment at higher numbers are most certainly not held by all experts in HIV medicine... tag:blogs.poz.com,2010:/joseph//36.2924 2010-06-26T15:30:56Z 2010-06-28T13:37:17Z

The reason I'm returning to this topic is that today I saw an article in the current Lancet Infectious Diseases entitled "Effect of treating co-infections on HIV-1 viral loads: a systematic review".

Joseph Sonnabend The reason I'm returning to this topic is that today I saw an article in the current Lancet Infectious Diseases entitled "Effect of treating co-infections on HIV-1 viral loads: a systematic review". tag:blogs.poz.com,2010:/joseph//36.2839 2010-05-18T14:10:14Z 2010-05-18T17:40:52Z

The combination of TB and HIV is devastating. Both are bad enough on their own, but together, each makes the other even more dangerous. This destructive combination is seen more frequently in South Africa than anywhere else in the world.

Joseph Sonnabend The combination of TB and HIV is devastating. Both are bad enough on their own, but together, each makes the other even more dangerous. This destructive combination is seen more frequently in South Africa than anywhere else in the world.